Transcription factors with Perturb-seq knockdown data for TRGV5P. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRGV5P upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRGV5P, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:38,335,451–38,336,337 | 9.2 kb | Proximal (<10kb) | 492 | |
| chr7:38,341,206–38,341,751 | 3.7 kb | Proximal (<10kb) | 243 | |
| chr7:38,345,442–38,345,962 | at TSS | At TSS | 80 | |
| chr7:38,349,794–38,350,278 | 4.3 kb | Proximal (<10kb) | 71 | |
| chr7:38,354,121–38,354,695 | 8.6 kb | Proximal (<10kb) | 77 |
Genomic view of the TRGV5P locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.