Enables transcription corepressor binding activity; transcription regulator inhibitor activity; and transmembrane transporter binding activity. Involved in positive regulation of gene expression and skeletal system development. Located in endoplasmic reticulum; nucleus; and perinuclear region of cytoplasm. Part of TRAPP complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TRAPPC2B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAPPC2B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAPPC2B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:57,191,186–57,191,993 | 172.0 kb | Distal (>10kb) Multiome | 712 | |
| chr19:57,240,050–57,241,126 | 123.0 kb | Distal (>10kb) Multiome | 809 | |
| chr19:57,279,622–57,281,023 | 83.2 kb | Distal (>10kb) Multiome | 1026 | |
| chr19:57,320,108–57,321,075 | 43.1 kb | Distal (>10kb) Multiome | 668 | |
| chr19:57,350,874–57,351,693 | 12.3 kb | Distal (>10kb) Multiome | 620 | |
| chr19:57,362,957–57,363,972 | 162 bp | At TSS Multiome | 697 | |
| chr19:57,389,420–57,390,542 | 26.3 kb | Distal (>10kb) Multiome | 722 | |
| chr19:57,410,944–57,411,658 | 47.6 kb | Distal (>10kb) Multiome | 612 | |
| chr19:57,434,797–57,436,077 | 71.8 kb | Distal (>10kb) Multiome | 742 | |
| chr19:57,477,251–57,477,789 | 114.0 kb | Distal (>10kb) Multiome | 582 | |
| chr19:57,487,570–57,488,036 | 124.2 kb | Distal (>10kb) Multiome | 483 | |
| chr19:57,499,726–57,500,208 | 136.4 kb | Distal (>10kb) Multiome | 523 | |
| chr19:57,527,148–57,527,898 | 163.8 kb | Distal (>10kb) Multiome | 711 | |
| chr19:57,559,528–57,559,978 | 196.3 kb | Distal (>10kb) Multiome | 564 | |
| chr19:57,578,473–57,579,216 | 215.4 kb | Distal (>10kb) Multiome | 668 | |
| chr19:57,583,416–57,584,426 | 220.5 kb | Distal (>10kb) Multiome | 462 | |
| chr19:57,599,699–57,600,175 | 236.3 kb | Distal (>10kb) Multiome | 646 | |
| chr19:57,614,049–57,614,534 | 250.7 kb | Distal (>10kb) Multiome | 661 | |
| chr19:57,632,786–57,633,679 | 269.6 kb | Distal (>10kb) Multiome | 652 |
Genomic view of the TRAPPC2B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.