The protein encoded by this gene is thought to be part of a large multi-subunit complex involved in the targeting and fusion of endoplasmic reticulum-to-Golgi transport vesicles with their acceptor compartment. In addition, the encoded protein can bind c-myc promoter-binding protein 1 and block its transcriptional repression capability. Mutations in this gene are a cause of spondyloepiphyseal dysplasia tarda (SEDT). A processed pseudogene of this gene is located on chromosome 19, and other pseudogenes are found on chromosomes 8 and Y. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for TRAPPC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAPPC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAPPC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:13,652,915–13,653,709 | 81.4 kb | Distal (>10kb) Multiome | 692 | |
| chrX:13,688,926–13,689,830 | 45.5 kb | Distal (>10kb) Multiome | 608 | |
| chrX:13,725,022–13,725,237 | 9.4 kb | Proximal (<10kb) | 9 | |
| chrX:13,734,289–13,735,335 | 101 bp | At TSS Multiome | 668 | |
| chrX:13,741,367–13,741,894 | 6.7 kb | Proximal (<10kb) | 14 | |
| chrX:13,937,416–13,939,477 | 203.9 kb | Distal (>10kb) Multiome | 380 | |
| chrX:14,029,131–14,030,229 | 295.2 kb | Distal (>10kb) Multiome HiCAR | 840 |
Genomic view of the TRAPPC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.