This gene encodes a protein that contains an N-terminal RING finger motif and a putative coiled-coil domain. A similar murine protein interacts with TNFR-associated factor 1 (TRAF1), TNFR-associated factor 2 (TRAF2), and cylindromatosis. The interaction with TRAF2 inhibits TRAF2-mediated nuclear factor kappa-B, subunit 1 activation that is required for cell activation and protection against apoptosis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TRAIP. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRAIP upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRAIP, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:49,718,116–49,720,106 | 136.9 kb | Distal (>10kb) Multiome HiCAR | 450 | |
| chr3:49,723,361–49,724,517 | 132.5 kb | Distal (>10kb) Multiome | 769 | |
| chr3:49,785,831–49,787,202 | 69.9 kb | Distal (>10kb) Multiome | 854 | |
| chr3:49,802,203–49,804,006 | 53.7 kb | Distal (>10kb) Multiome | 733 | |
| chr3:49,856,099–49,857,163 | 99 bp | At TSS Multiome | 664 | |
| chr3:49,869,590–49,870,249 | 13.4 kb | Distal (>10kb) Multiome | 251 | |
| chr3:49,903,411–49,904,277 | 47.4 kb | Distal (>10kb) Multiome HiCAR | 415 | |
| chr3:49,929,290–49,930,212 | 73.2 kb | Distal (>10kb) Multiome | 799 | |
| chr3:49,939,635–49,940,747 | 83.5 kb | Distal (>10kb) Multiome | 949 | |
| chr3:50,088,748–50,089,596 | 232.4 kb | Distal (>10kb) Multiome | 677 | |
| chr3:50,121,279–50,122,037 | 265.2 kb | Distal (>10kb) Multiome | 364 | |
| chr3:50,138,509–50,140,035 | 282.8 kb | Distal (>10kb) Multiome | 198 | |
| chr3:50,154,437–50,155,741 | 298.5 kb | Distal (>10kb) Multiome | 450 |
Genomic view of the TRAIP locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.