The protein encoded by this gene is a death domain containing adaptor molecule that interacts with TNFRSF1A/TNFR1 and mediates programmed cell death signaling and NF-kappaB activation. This protein binds adaptor protein TRAF2, reduces the recruitment of inhibitor-of-apoptosis proteins (IAPs) by TRAF2, and thus suppresses TRAF2 mediated apoptosis. This protein can also interact with receptor TNFRSF6/FAS and adaptor protein FADD/MORT1, and is involved in the Fas-induced cell death pathway. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TRADD. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TRADD upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TRADD, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:67,149,282–67,151,406 | 4.0 kb | Proximal (<10kb) | 693 | |
| chr16:67,154,687–67,155,820 | at TSS | At TSS | 593 | |
| chr16:67,159,109–67,160,527 | 3.7 kb | Proximal (<10kb) | 721 | |
| chr16:67,160,628–67,161,206 | 5.2 kb | Proximal (<10kb) | 524 | |
| chr16:67,162,969–67,163,815 | 7.6 kb | Proximal (<10kb) | 238 | |
| chr16:67,169,105–67,171,287 | 9.2 kb | Proximal (<10kb) | 813 |
Genomic view of the TRADD locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.