This locus encodes a sensory epithelial protein. It was defined by linkage analysis in three Pakistani families to lie between D9S1818 (centromeric) and D9SH6 (telomeric). Mutations at this locus have been associated with autosomal recessive deafness. [provided by RefSeq, Oct 2010]
Transcription factors with Perturb-seq knockdown data for TPRN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPRN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPRN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:136,943,250–136,945,621 | 256.1 kb | Distal (>10kb) Multiome | 883 | |
| chr9:136,949,631–136,950,846 | 250.6 kb | Distal (>10kb) Multiome | 776 | |
| chr9:136,977,106–136,980,430 | 222.2 kb | Distal (>10kb) Multiome | 413 | |
| chr9:136,991,827–136,993,248 | 208.4 kb | Distal (>10kb) Multiome | 720 | |
| chr9:137,027,536–137,029,054 | 172.5 kb | Distal (>10kb) Multiome | 539 | |
| chr9:137,029,231–137,029,652 | 171.2 kb | Distal (>10kb) Multiome | 386 | |
| chr9:137,045,334–137,046,838 | 154.2 kb | Distal (>10kb) Multiome | 829 | |
| chr9:137,053,352–137,054,892 | 146.6 kb | Distal (>10kb) Multiome | 544 | |
| chr9:137,067,810–137,068,494 | 132.6 kb | Distal (>10kb) Multiome HiCAR | 492 | |
| chr9:137,069,879–137,071,138 | 130.1 kb | Distal (>10kb) Multiome | 703 | |
| chr9:137,076,758–137,078,723 | 123.3 kb | Distal (>10kb) Multiome | 530 | |
| chr9:137,085,844–137,087,716 | 113.9 kb | Distal (>10kb) Multiome | 890 | |
| chr9:137,129,244–137,130,499 | 70.9 kb | Distal (>10kb) Multiome HiCAR | 823 | |
| chr9:137,167,984–137,170,155 | 31.3 kb | Distal (>10kb) Multiome | 560 | |
| chr9:137,188,099–137,189,538 | 12.0 kb | Distal (>10kb) Multiome | 954 | |
| chr9:137,199,427–137,200,043 | 697 bp | At TSS | 193 | |
| chr9:137,200,175–137,201,689 | 136 bp | At TSS Multiome | 856 | |
| chr9:137,205,371–137,205,975 | 4.9 kb | Proximal (<10kb) Multiome | 758 | |
| chr9:137,221,373–137,224,294 | 21.2 kb | Distal (>10kb) Multiome HiCAR | 843 | |
| chr9:137,227,249–137,228,051 | 26.9 kb | Distal (>10kb) Multiome HiCAR | 533 | |
| chr9:137,236,161–137,237,143 | 35.9 kb | Distal (>10kb) Multiome | 748 | |
| chr9:137,239,991–137,242,933 | 40.3 kb | Distal (>10kb) Multiome | 1117 | |
| chr9:137,243,659–137,245,307 | 43.6 kb | Distal (>10kb) Multiome | 471 | |
| chr9:137,253,801–137,256,036 | 54.6 kb | Distal (>10kb) Multiome | 843 | |
| chr9:137,280,593–137,281,861 | 80.4 kb | Distal (>10kb) Multiome | 223 | |
| chr9:137,294,859–137,296,916 | 94.8 kb | Distal (>10kb) Multiome | 501 | |
| chr9:137,300,591–137,303,141 | 101.7 kb | Distal (>10kb) Multiome | 790 | |
| chr9:137,316,104–137,316,916 | 115.6 kb | Distal (>10kb) Multiome | 395 | |
| chr9:137,406,843–137,407,556 | 206.4 kb | Distal (>10kb) Multiome | 427 | |
| chr9:137,422,664–137,424,024 | 222.5 kb | Distal (>10kb) Multiome | 896 | |
| chr9:137,441,270–137,441,970 | 240.8 kb | Distal (>10kb) Multiome | 568 | |
| chr9:137,453,153–137,455,543 | 253.3 kb | Distal (>10kb) Multiome | 727 | |
| chr9:137,458,468–137,459,887 | 258.6 kb | Distal (>10kb) Multiome | 613 | |
| chr9:137,461,555–137,462,160 | 261.1 kb | Distal (>10kb) Multiome | 284 |
Genomic view of the TPRN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.