This gene encodes a leucine-rich transmembrane glycoprotein that may be involved in cell adhesion. The encoded protein is an oncofetal antigen that is specific to trophoblast cells. In adults this protein is highly expressed in many tumor cells and is associated with poor clinical outcome in numerous cancers. Alternate splicing in the 5' UTR results in multiple transcript variants that encode the same protein. [provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for TPBG. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TPBG upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TPBG, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:82,246,942–82,248,798 | 116.0 kb | Distal (>10kb) Multiome | 957 | |
| chr6:82,256,786–82,258,089 | 106.5 kb | Distal (>10kb) Multiome | 171 | |
| chr6:82,363,222–82,366,030 | 1 bp | At TSS Multiome | 857 | |
| chr6:82,370,879–82,371,059 | 7.1 kb | Proximal (<10kb) | 45 | |
| chr6:82,607,708–82,609,057 | 244.5 kb | Distal (>10kb) Multiome HiCAR | 138 | |
| chr6:83,065,409–83,066,246 | 702.0 kb | Distal (>10kb) Multiome HiCAR | 863 | |
| chr6:83,067,273–83,069,447 | 704.1 kb | Distal (>10kb) Multiome HiCAR | 1006 |
Genomic view of the TPBG locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.