Involved in negative regulation of cell cycle; response to UV; and response to xenobiotic stimulus. Located in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TP53I13. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TP53I13 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TP53I13, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:29,292,464–29,294,599 | 274.4 kb | Distal (>10kb) Multiome HiCAR | 1029 | |
| chr17:29,369,902–29,370,603 | 197.0 kb | Distal (>10kb) Multiome HiCAR | 305 | |
| chr17:29,389,919–29,391,325 | 176.9 kb | Distal (>10kb) Multiome HiCAR | 863 | |
| chr17:29,566,006–29,569,574 | 1.5 kb | Proximal (<10kb) Multiome | 868 | |
| chr17:29,572,746–29,573,303 | 5.8 kb | Proximal (<10kb) Multiome | 252 | |
| chr17:29,588,688–29,590,312 | 22.5 kb | Distal (>10kb) Multiome | 590 | |
| chr17:29,590,975–29,592,562 | 24.6 kb | Distal (>10kb) Multiome | 810 | |
| chr17:29,612,906–29,613,942 | 46.4 kb | Distal (>10kb) Multiome | 581 | |
| chr17:29,614,997–29,616,357 | 48.5 kb | Distal (>10kb) Multiome | 389 | |
| chr17:29,616,988–29,618,466 | 51.0 kb | Distal (>10kb) Multiome | 615 | |
| chr17:29,622,374–29,623,287 | 55.7 kb | Distal (>10kb) Multiome | 470 | |
| chr17:29,761,028–29,761,644 | 194.2 kb | Distal (>10kb) Multiome | 643 |
Genomic view of the TP53I13 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.