Predicted to be involved in negative regulation of cell population proliferation. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TP53I11. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TP53I11 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TP53I11, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:44,725,781–44,728,323 | 222.9 kb | Distal (>10kb) Multiome | 573 | |
| chr11:44,761,126–44,761,961 | 189.4 kb | Distal (>10kb) Multiome | 179 | |
| chr11:44,823,949–44,825,281 | 126.5 kb | Distal (>10kb) Multiome | 179 | |
| chr11:44,862,158–44,862,936 | 88.4 kb | Distal (>10kb) Multiome | 435 | |
| chr11:44,893,997–44,894,680 | 56.6 kb | Distal (>10kb) Multiome | 245 | |
| chr11:44,911,150–44,911,857 | 39.4 kb | Distal (>10kb) Multiome | 202 | |
| chr11:44,949,162–44,951,290 | 1.2 kb | Proximal (<10kb) Multiome | 458 | |
| chr11:44,954,146–44,954,620 | 3.5 kb | Proximal (<10kb) Multiome | 48 | |
| chr11:44,977,463–44,978,182 | 26.9 kb | Distal (>10kb) Multiome | 120 | |
| chr11:45,146,509–45,147,702 | 196.3 kb | Distal (>10kb) Multiome | 678 | |
| chr11:45,180,177–45,181,500 | 229.9 kb | Distal (>10kb) Multiome | 508 |
Genomic view of the TP53I11 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.