The protein encoded by this gene is an ATPase found primarily in the endoplasmic reticulum and nuclear envelope. This gene has a highly-similar neighboring gene, TOR1A, that encodes a protein that is likely to interact in a complex with this protein. Finally, this protein may act as a chaperone and play a role in maintaining the integrity of the nuclear envelope and endoplasmic reticulum. Several transcript variants, some protein-coding and others non-protein coding, have been found for this gene. [provided by RefSeq, Dec 2015]
Transcription factors with Perturb-seq knockdown data for TOR1B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOR1B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOR1B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:129,557,196–129,557,935 | 245.6 kb | Distal (>10kb) Multiome | 718 | |
| chr9:129,596,686–129,597,656 | 206.1 kb | Distal (>10kb) Multiome | 700 | |
| chr9:129,610,548–129,611,334 | 192.3 kb | Distal (>10kb) Multiome | 630 | |
| chr9:129,626,055–129,626,580 | 177.0 kb | Distal (>10kb) Multiome | 825 | |
| chr9:129,641,895–129,642,673 | 160.9 kb | Distal (>10kb) Multiome | 919 | |
| chr9:129,802,988–129,803,555 | 1 bp | At TSS Multiome | 727 | |
| chr9:129,835,192–129,835,687 | 32.2 kb | Distal (>10kb) Multiome | 701 | |
| chr9:130,042,478–130,043,723 | 240.1 kb | Distal (>10kb) Multiome | 793 |
Genomic view of the TOR1B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.