Enables mitochondrion targeting sequence binding activity; protein-transporting ATPase activity; and unfolded protein binding activity. Involved in protein targeting to mitochondrion. Located in mitochondria-associated endoplasmic reticulum membrane contact site and mitochondrial outer membrane. Is active in mitochondrion. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TOMM20. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOMM20 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOMM20, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:234,957,467–234,958,020 | 171.1 kb | Distal (>10kb) Multiome | 794 | |
| chr1:235,093,150–235,094,131 | 35.1 kb | Distal (>10kb) Multiome | 491 | |
| chr1:235,128,387–235,130,613 | 1.3 kb | Proximal (<10kb) Multiome | 1042 | |
| chr1:235,160,743–235,162,007 | 32.4 kb | Distal (>10kb) Multiome | 1015 | |
| chr1:235,304,634–235,305,365 | 176.2 kb | Distal (>10kb) Multiome | 220 | |
| chr1:235,326,947–235,329,481 | 199.7 kb | Distal (>10kb) Multiome | 1010 | |
| chr1:235,367,126–235,367,788 | 238.6 kb | Distal (>10kb) Multiome | 851 |
Genomic view of the TOMM20 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.