This gene was identified as a target of the v-myb oncogene. The encoded protein shares its N-terminal domain in common with proteins associated with vesicular trafficking at the endosome. It is recruited to the endosomes by its interaction with endofin. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Transcription factors with Perturb-seq knockdown data for TOM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TOM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TOM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr22:35,134,690–35,135,283 | 165.0 kb | Distal (>10kb) Multiome | 87 | |
| chr22:35,257,329–35,258,076 | 42.3 kb | Distal (>10kb) Multiome | 851 | |
| chr22:35,299,271–35,300,787 | 83 bp | At TSS Multiome | 908 | |
| chr22:35,350,767–35,351,264 | 51.1 kb | Distal (>10kb) Multiome | 589 | |
| chr22:35,371,784–35,372,565 | 72.2 kb | Distal (>10kb) Multiome | 874 | |
| chr22:35,376,743–35,377,378 | 77.2 kb | Distal (>10kb) Multiome | 810 | |
| chr22:35,399,845–35,400,552 | 100.2 kb | Distal (>10kb) Multiome | 740 | |
| chr22:35,539,918–35,540,941 | 240.6 kb | Distal (>10kb) Multiome | 411 |
Genomic view of the TOM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.