Predicted to enable RNA binding activity. Involved in miRNA-mediated post-transcriptional gene silencing; positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay; and positive regulation of nuclear-transcribed mRNA poly(A) tail shortening. Predicted to be located in cytosol. Predicted to be active in P-body and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TNRC6C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNRC6C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNRC6C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:77,915,676–77,916,129 | 42.8 kb | Distal (>10kb) Multiome | 105 | |
| chr17:77,935,380–77,936,363 | 22.8 kb | Distal (>10kb) Multiome | 171 | |
| chr17:77,957,585–77,959,667 | 179 bp | At TSS Multiome | 1117 | |
| chr17:78,127,361–78,129,338 | 170.1 kb | Distal (>10kb) Multiome | 909 | |
| chr17:78,140,136–78,141,130 | 181.9 kb | Distal (>10kb) Multiome | 594 | |
| chr17:78,168,117–78,169,078 | 209.8 kb | Distal (>10kb) Multiome | 738 | |
| chr17:78,186,463–78,187,739 | 228.5 kb | Distal (>10kb) Multiome | 1021 | |
| chr17:78,213,978–78,214,702 | 255.5 kb | Distal (>10kb) Multiome | 902 | |
| chr17:78,231,715–78,232,315 | 273.3 kb | Distal (>10kb) Multiome | 147 | |
| chr17:78,250,689–78,251,651 | 292.4 kb | Distal (>10kb) Multiome | 714 | |
| chr17:78,254,178–78,254,892 | 295.8 kb | Distal (>10kb) Multiome | 860 | |
| chr17:78,270,255–78,273,257 | 313.7 kb | Distal (>10kb) Multiome | 667 | |
| chr17:78,278,089–78,278,902 | 319.8 kb | Distal (>10kb) Multiome | 225 |
Genomic view of the TNRC6C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.