The protein encoded by this gene is a cytokine that belongs to the tumor necrosis factor (TNF) ligand family. This cytokine is a ligand for receptors TNFRSF13B/TACI, TNFRSF17/BCMA, and TNFRSF13C/BAFFR. This cytokine is expressed in B cell lineage cells, and acts as a potent B cell activator. It has been also shown to play an important role in the proliferation and differentiation of B cells. Alternatively spliced transcript variants encoding distinct isoforms have been identified. [provided by RefSeq, Mar 2011]
Transcription factors with Perturb-seq knockdown data for TNFSF13B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNFSF13B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNFSF13B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr13:108,215,115–108,215,948 | 54.6 kb | Distal (>10kb) Multiome | 468 | |
| chr13:108,217,843–108,219,001 | 51.8 kb | Distal (>10kb) Multiome | 875 | |
| chr13:108,263,857–108,264,319 | 5.9 kb | Proximal (<10kb) | 14 | |
| chr13:108,269,721–108,270,542 | at TSS | At TSS | 285 | |
| chr13:109,782,909–109,788,044 | 1516.6 kb | Distal (>10kb) Multiome HiCAR | 731 |
Genomic view of the TNFSF13B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.