The protein encoded by this gene is a member of the TNF-receptor superfamily. This receptor is activated by tumor necrosis factor-related apoptosis inducing ligand (TNFSF10/TRAIL), and thus transduces cell death signal and induces cell apoptosis. Studies with FADD-deficient mice suggested that FADD, a death domain containing adaptor protein, is required for the apoptosis mediated by this protein. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TNFRSF10A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNFRSF10A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNFRSF10A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:22,998,974–23,000,300 | 225.5 kb | Distal (>10kb) Multiome | 597 | |
| chr8:23,019,069–23,020,109 | 205.7 kb | Distal (>10kb) Multiome | 452 | |
| chr8:23,068,457–23,069,444 | 156.1 kb | Distal (>10kb) Multiome | 856 | |
| chr8:23,083,702–23,084,469 | 140.8 kb | Distal (>10kb) Multiome | 538 | |
| chr8:23,162,920–23,164,386 | 61.4 kb | Distal (>10kb) Multiome | 808 | |
| chr8:23,224,394–23,225,450 | 156 bp | At TSS Multiome | 678 | |
| chr8:23,246,206–23,247,324 | 21.6 kb | Distal (>10kb) Multiome | 941 | |
| chr8:23,287,908–23,288,715 | 63.0 kb | Distal (>10kb) Multiome | 853 | |
| chr8:23,403,157–23,405,109 | 179.1 kb | Distal (>10kb) Multiome | 425 | |
| chr8:23,457,148–23,458,219 | 232.5 kb | Distal (>10kb) Multiome | 736 |
Genomic view of the TNFRSF10A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.