This gene was identified as a gene whose expression can be induced by the tumor necrosis factor alpha (TNF) in umbilical vein endothelial cells. The expression of this gene was shown to be induced by retinoic acid in a cell line expressing a oncogenic version of the retinoic acid receptor alpha fusion protein, which suggested that this gene may be a retinoic acid target gene in acute promyelocytic leukemia. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TNFAIP2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TNFAIP2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TNFAIP2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:102,927,667–102,929,100 | 194.9 kb | Distal (>10kb) Multiome | 328 | |
| chr14:102,929,570–102,930,980 | 193.1 kb | Distal (>10kb) Multiome | 178 | |
| chr14:102,954,209–102,955,338 | 168.5 kb | Distal (>10kb) Multiome | 143 | |
| chr14:103,056,337–103,058,497 | 65.8 kb | Distal (>10kb) Multiome | 644 | |
| chr14:103,075,052–103,076,162 | 47.7 kb | Distal (>10kb) Multiome | 656 | |
| chr14:103,091,357–103,091,855 | 31.8 kb | Distal (>10kb) Multiome | 384 | |
| chr14:103,104,655–103,105,370 | 18.3 kb | Distal (>10kb) Multiome | 618 | |
| chr14:103,121,910–103,122,496 | 5.1 kb | Proximal (<10kb) | 448 | |
| chr14:103,122,605–103,123,921 | 369 bp | At TSS Multiome | 378 | |
| chr14:103,126,688–103,127,597 | 3.7 kb | Proximal (<10kb) Multiome | 313 | |
| chr14:103,188,912–103,189,569 | 65.8 kb | Distal (>10kb) Multiome | 138 | |
| chr14:103,207,129–103,207,830 | 84.0 kb | Distal (>10kb) Multiome | 200 | |
| chr14:103,333,053–103,335,386 | 210.7 kb | Distal (>10kb) Multiome | 1004 | |
| chr14:103,384,755–103,386,021 | 261.9 kb | Distal (>10kb) Multiome | 863 |
Genomic view of the TNFAIP2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.