Transcription factors with Perturb-seq knockdown data for TMSB15B-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMSB15B-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMSB15B-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:103,686,434–103,687,597 | 232.2 kb | Distal (>10kb) Multiome | 737 | |
| chrX:103,831,529–103,832,547 | 87.0 kb | Distal (>10kb) Multiome | 250 | |
| chrX:103,918,085–103,918,389 | 698 bp | At TSS | 75 | |
| chrX:103,918,585–103,919,659 | 122 bp | At TSS Multiome | 303 | |
| chrX:104,111,937–104,113,017 | 193.4 kb | Distal (>10kb) Multiome | 274 | |
| chrX:104,156,439–104,157,507 | 237.8 kb | Distal (>10kb) Multiome | 771 | |
| chrX:104,165,815–104,167,017 | 247.3 kb | Distal (>10kb) Multiome | 651 |
Genomic view of the TMSB15B-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.