Located in nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM92. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM92 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM92, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:49,993,266–49,993,947 | 280.9 kb | Distal (>10kb) Multiome | 222 | |
| chr17:49,994,638–49,995,383 | 279.3 kb | Distal (>10kb) Multiome | 281 | |
| chr17:49,996,642–49,997,221 | 277.6 kb | Distal (>10kb) Multiome | 470 | |
| chr17:50,055,522–50,057,280 | 218.5 kb | Distal (>10kb) Multiome | 654 | |
| chr17:50,094,331–50,095,951 | 179.2 kb | Distal (>10kb) Multiome | 899 | |
| chr17:50,117,038–50,117,876 | 157.1 kb | Distal (>10kb) Multiome | 488 | |
| chr17:50,150,777–50,152,506 | 123.4 kb | Distal (>10kb) Multiome | 900 | |
| chr17:50,161,052–50,162,135 | 112.9 kb | Distal (>10kb) Multiome | 691 | |
| chr17:50,177,880–50,178,665 | 96.1 kb | Distal (>10kb) Multiome | 675 | |
| chr17:50,199,586–50,201,292 | 74.0 kb | Distal (>10kb) Multiome HiCAR | 798 | |
| chr17:50,270,196–50,270,370 | 4.1 kb | Proximal (<10kb) | 167 | |
| chr17:50,273,066–50,273,646 | 1.2 kb | Proximal (<10kb) Multiome | 411 | |
| chr17:50,274,084–50,274,945 | 53 bp | At TSS Multiome | 242 | |
| chr17:50,310,314–50,311,981 | 37.2 kb | Distal (>10kb) Multiome | 314 | |
| chr17:50,312,127–50,312,775 | 38.2 kb | Distal (>10kb) Multiome | 37 | |
| chr17:50,345,523–50,346,998 | 71.7 kb | Distal (>10kb) Multiome | 809 | |
| chr17:50,363,392–50,364,195 | 89.4 kb | Distal (>10kb) Multiome | 164 | |
| chr17:50,372,860–50,373,487 | 98.7 kb | Distal (>10kb) Multiome | 999 | |
| chr17:50,397,227–50,397,885 | 123.1 kb | Distal (>10kb) Multiome | 1045 | |
| chr17:50,425,595–50,426,626 | 151.8 kb | Distal (>10kb) Multiome | 619 | |
| chr17:50,478,411–50,479,262 | 204.4 kb | Distal (>10kb) Multiome | 956 | |
| chr17:50,508,047–50,508,856 | 234.0 kb | Distal (>10kb) Multiome | 332 | |
| chr17:50,541,672–50,542,697 | 267.7 kb | Distal (>10kb) Multiome | 772 | |
| chr17:50,546,778–50,547,615 | 272.7 kb | Distal (>10kb) Multiome | 786 | |
| chr17:50,558,590–50,561,781 | 286.1 kb | Distal (>10kb) Multiome | 587 |
Genomic view of the TMEM92 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.