Enables calcium-activated cation channel activity. Involved in monoatomic cation transport. Predicted to be located in endoplasmic reticulum membrane. Predicted to be active in plasma membrane. Implicated in hereditary spastic paraplegia 87. Biomarker of focal segmental glomerulosclerosis. [provided by Alliance of Genome Resources, Apr 2025]
Transcription factors with Perturb-seq knockdown data for TMEM63C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM63C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM63C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:76,913,323–76,913,886 | 268.0 kb | Distal (>10kb) Multiome | 352 | |
| chr14:76,924,332–76,925,072 | 256.9 kb | Distal (>10kb) Multiome | 256 | |
| chr14:76,947,024–76,947,904 | 234.1 kb | Distal (>10kb) Multiome | 690 | |
| chr14:76,955,827–76,957,395 | 225.1 kb | Distal (>10kb) Multiome | 873 | |
| chr14:76,961,044–76,962,678 | 219.7 kb | Distal (>10kb) Multiome | 848 | |
| chr14:76,968,574–76,969,080 | 212.7 kb | Distal (>10kb) Multiome | 311 | |
| chr14:77,024,027–77,024,710 | 157.3 kb | Distal (>10kb) Multiome | 368 | |
| chr14:77,025,547–77,029,182 | 152.9 kb | Distal (>10kb) Multiome | 996 | |
| chr14:77,032,573–77,034,628 | 148.4 kb | Distal (>10kb) Multiome | 917 | |
| chr14:77,040,063–77,040,913 | 141.1 kb | Distal (>10kb) Multiome | 765 | |
| chr14:77,088,297–77,088,792 | 93.1 kb | Distal (>10kb) Multiome | 234 | |
| chr14:77,097,312–77,099,236 | 83.5 kb | Distal (>10kb) Multiome | 948 | |
| chr14:77,124,505–77,125,759 | 56.6 kb | Distal (>10kb) Multiome | 289 | |
| chr14:77,139,459–77,142,559 | 41.8 kb | Distal (>10kb) Multiome | 507 | |
| chr14:77,181,185–77,182,207 | 78 bp | At TSS Multiome | 485 | |
| chr14:77,270,588–77,271,586 | 89.5 kb | Distal (>10kb) Multiome | 147 | |
| chr14:77,320,198–77,322,121 | 139.5 kb | Distal (>10kb) Multiome | 915 | |
| chr14:77,376,423–77,377,683 | 195.5 kb | Distal (>10kb) Multiome | 630 | |
| chr14:77,456,961–77,458,831 | 276.1 kb | Distal (>10kb) Multiome | 878 |
Genomic view of the TMEM63C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.