Predicted to enable hydrolase activity. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM62. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM62 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM62, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:42,920,326–42,921,183 | 212.7 kb | Distal (>10kb) Multiome | 689 | |
| chr15:43,133,378–43,134,025 | at TSS | At TSS | 732 | |
| chr15:43,184,963–43,185,969 | 51.8 kb | Distal (>10kb) Multiome | 807 | |
| chr15:43,330,217–43,330,762 | 196.9 kb | Distal (>10kb) Multiome | 845 | |
| chr15:43,370,765–43,371,726 | 237.7 kb | Distal (>10kb) Multiome | 774 |
Genomic view of the TMEM62 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.