Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM60. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM60 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM60, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:77,536,195–77,538,947 | 261.5 kb | Distal (>10kb) Multiome | 1033 | |
| chr7:77,695,815–77,697,645 | 102.1 kb | Distal (>10kb) Multiome | 929 | |
| chr7:77,797,902–77,799,769 | 220 bp | At TSS Multiome | 1053 | |
| chr7:78,019,077–78,020,812 | 221.4 kb | Distal (>10kb) Multiome | 625 | |
| chr7:78,040,136–78,040,886 | 242.0 kb | Distal (>10kb) Multiome | 297 | |
| chr7:78,051,906–78,052,643 | 253.9 kb | Distal (>10kb) Multiome | 182 | |
| chr7:78,054,662–78,056,159 | 257.3 kb | Distal (>10kb) Multiome | 259 | |
| chr7:78,073,306–78,074,574 | 275.6 kb | Distal (>10kb) Multiome | 276 |
Genomic view of the TMEM60 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.