Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM52. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM52 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM52, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:1,628,379–1,632,529 | 289.1 kb | Distal (>10kb) Multiome | 552 | |
| chr1:1,658,722–1,659,418 | 260.1 kb | Distal (>10kb) Multiome | 602 | |
| chr1:1,724,054–1,724,738 | 194.8 kb | Distal (>10kb) Multiome | 631 | |
| chr1:1,777,637–1,780,173 | 140.4 kb | Distal (>10kb) Multiome | 970 | |
| chr1:1,782,008–1,783,229 | 137.0 kb | Distal (>10kb) Multiome HiCAR | 590 | |
| chr1:1,890,319–1,891,952 | 28.0 kb | Distal (>10kb) Multiome | 748 | |
| chr1:1,908,308–1,910,312 | 10.1 kb | Distal (>10kb) Multiome | 801 | |
| chr1:1,918,258–1,920,500 | 182 bp | At TSS Multiome | 820 | |
| chr1:1,959,901–1,960,517 | 40.9 kb | Distal (>10kb) Multiome | 594 | |
| chr1:2,019,137–2,019,982 | 100.2 kb | Distal (>10kb) Multiome | 288 | |
| chr1:2,049,277–2,050,992 | 131.0 kb | Distal (>10kb) Multiome | 732 | |
| chr1:2,132,340–2,134,100 | 214.2 kb | Distal (>10kb) Multiome | 508 | |
| chr1:2,189,382–2,190,314 | 270.4 kb | Distal (>10kb) Multiome | 719 | |
| chr1:2,194,502–2,195,788 | 275.8 kb | Distal (>10kb) Multiome | 789 | |
| chr1:2,199,148–2,199,756 | 280.2 kb | Distal (>10kb) Multiome | 445 | |
| chr1:2,204,191–2,206,396 | 285.8 kb | Distal (>10kb) Multiome | 597 | |
| chr1:2,212,255–2,213,305 | 293.4 kb | Distal (>10kb) Multiome | 601 | |
| chr1:3,649,785–3,650,304 | 1730.8 kb | Distal (>10kb) Multiome HiCAR | 620 | |
| chr1:3,651,921–3,653,136 | 1733.6 kb | Distal (>10kb) Multiome HiCAR | 369 |
Genomic view of the TMEM52 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.