This gene is located in the RH gene locus, between the RHD and RHCE genes. The function of its protein product is unknown; however, its sequence has potential transmembrane domains suggesting that it may be an integral membrane protein. Its position between the RH genes suggests that polymorphisms in this gene may be tightly linked to RH haplotypes and may contribute to selective pressure for or against certain RH haplotypes. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TMEM50A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM50A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM50A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:25,232,067–25,232,905 | 105.8 kb | Distal (>10kb) Multiome | 757 | |
| chr1:25,233,146–25,233,599 | 105.0 kb | Distal (>10kb) Multiome | 493 | |
| chr1:25,239,634–25,240,475 | 98.4 kb | Distal (>10kb) Multiome | 897 | |
| chr1:25,246,452–25,248,229 | 90.7 kb | Distal (>10kb) Multiome | 1054 | |
| chr1:25,338,116–25,338,949 | 132 bp | At TSS Multiome | 803 | |
| chr1:25,429,935–25,431,604 | 91.9 kb | Distal (>10kb) Multiome | 845 | |
| chr1:25,543,218–25,544,436 | 205.3 kb | Distal (>10kb) Multiome | 569 | |
| chr1:25,615,967–25,618,316 | 278.3 kb | Distal (>10kb) Multiome | 585 |
Genomic view of the TMEM50A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.