Predicted to enable potassium channel activity. Predicted to be involved in regulation of release of sequestered calcium ion into cytosol. Predicted to act upstream of or within several processes, including cellular response to caffeine; monoatomic cation transmembrane transport; and regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion. Located in extracellular exosome. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM38A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM38A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM38A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:16,471,332–16,472,638 | 189.1 kb | Distal (>10kb) Multiome | 645 | |
| chr19:16,495,870–16,496,694 | 164.9 kb | Distal (>10kb) Multiome | 780 | |
| chr19:16,541,995–16,543,080 | 118.6 kb | Distal (>10kb) Multiome | 880 | |
| chr19:16,571,833–16,572,764 | 88.6 kb | Distal (>10kb) Multiome | 814 | |
| chr19:16,627,176–16,629,209 | 32.8 kb | Distal (>10kb) Multiome | 896 | |
| chr19:16,659,555–16,661,823 | 1.0 kb | Proximal (<10kb) Multiome | 987 | |
| chr19:16,828,911–16,830,011 | 168.2 kb | Distal (>10kb) Multiome | 623 | |
| chr19:16,895,945–16,898,066 | 236.1 kb | Distal (>10kb) Multiome | 632 |
Genomic view of the TMEM38A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.