This locus represents naturally occurring read-through transcription between the neighboring LOC84773 and cysteine and histidine rich 1 (CYHR1). It encodes a fusion protein that shares sequence identity with proteins encoded by both independent genes. [provided by RefSeq, Feb 2022]
Transcription factors with Perturb-seq knockdown data for TMEM276-ZFTRAF1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM276-ZFTRAF1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM276-ZFTRAF1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:144,462,568–144,463,422 | 2.0 kb | Proximal (<10kb) | 548 | |
| chr8:144,463,885–144,468,178 | at TSS | At TSS | 910 | |
| chr8:144,471,960–144,474,391 | 6.5 kb | Proximal (<10kb) | 482 | |
| chr8:144,474,517–144,476,543 | 9.1 kb | Proximal (<10kb) | 321 |
Genomic view of the TMEM276-ZFTRAF1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.