Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM253. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM253 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM253, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:21,090,364–21,090,552 | 8.3 kb | Proximal (<10kb) | 239 | |
| chr14:21,092,184–21,093,275 | 5.5 kb | Proximal (<10kb) | 774 | |
| chr14:21,094,184–21,094,833 | 4.0 kb | Proximal (<10kb) | 210 | |
| chr14:21,097,193–21,098,877 | at TSS | At TSS | 469 | |
| chr14:21,103,222–21,104,876 | 4.4 kb | Proximal (<10kb) | 1128 | |
| chr14:21,106,944–21,107,347 | 8.1 kb | Proximal (<10kb) | 504 |
Genomic view of the TMEM253 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.