Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM248. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM248 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM248, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:66,627,961–66,629,582 | 292.4 kb | Distal (>10kb) Multiome | 896 | |
| chr7:66,654,134–66,655,326 | 266.7 kb | Distal (>10kb) Multiome | 1021 | |
| chr7:66,681,738–66,682,647 | 239.1 kb | Distal (>10kb) Multiome | 840 | |
| chr7:66,740,305–66,741,524 | 180.5 kb | Distal (>10kb) Multiome | 898 | |
| chr7:66,844,266–66,845,342 | 76.3 kb | Distal (>10kb) Multiome | 851 | |
| chr7:66,919,347–66,919,723 | 1.5 kb | Proximal (<10kb) | 71 | |
| chr7:66,920,765–66,921,508 | 39 bp | At TSS Multiome | 957 | |
| chr7:66,930,360–66,930,603 | 9.1 kb | Proximal (<10kb) | 265 | |
| chr7:66,995,101–66,995,823 | 74.3 kb | Distal (>10kb) Multiome | 496 | |
| chr7:66,996,514–66,997,168 | 75.6 kb | Distal (>10kb) Multiome | 407 | |
| chr7:67,099,256–67,099,739 | 178.3 kb | Distal (>10kb) Multiome | 33 | |
| chr7:67,179,175–67,179,622 | 258.2 kb | Distal (>10kb) Multiome | 83 |
Genomic view of the TMEM248 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.