Predicted to be involved in apoptotic process. Located in several cellular components, including Golgi apparatus; cytoplasmic microtubule; and endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM214. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM214 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM214, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:26,749,944–26,750,505 | 282.8 kb | Distal (>10kb) Multiome | 322 | |
| chr2:26,764,126–26,764,575 | 268.7 kb | Distal (>10kb) Multiome | 781 | |
| chr2:26,785,402–26,786,601 | 247.1 kb | Distal (>10kb) Multiome | 996 | |
| chr2:26,846,388–26,846,855 | 186.4 kb | Distal (>10kb) Multiome | 343 | |
| chr2:26,847,436–26,849,494 | 185.0 kb | Distal (>10kb) Multiome | 447 | |
| chr2:26,961,589–26,962,066 | 71.1 kb | Distal (>10kb) Multiome HiCAR | 502 | |
| chr2:26,970,294–26,971,331 | 62.4 kb | Distal (>10kb) Multiome HiCAR | 572 | |
| chr2:27,032,577–27,033,271 | 44 bp | At TSS Multiome | 799 | |
| chr2:27,049,564–27,052,299 | 17.8 kb | Distal (>10kb) Multiome | 1295 | |
| chr2:27,071,223–27,072,896 | 38.8 kb | Distal (>10kb) Multiome | 864 | |
| chr2:27,081,006–27,081,641 | 48.4 kb | Distal (>10kb) Multiome | 758 | |
| chr2:27,085,591–27,087,452 | 53.7 kb | Distal (>10kb) Multiome | 970 | |
| chr2:27,123,498–27,124,089 | 90.9 kb | Distal (>10kb) Multiome | 553 | |
| chr2:27,133,917–27,135,216 | 101.7 kb | Distal (>10kb) Multiome | 815 | |
| chr2:27,211,255–27,212,840 | 179.2 kb | Distal (>10kb) Multiome | 978 | |
| chr2:27,217,045–27,218,005 | 184.4 kb | Distal (>10kb) Multiome | 771 | |
| chr2:27,250,040–27,250,883 | 217.4 kb | Distal (>10kb) Multiome | 559 | |
| chr2:27,262,260–27,263,337 | 230.0 kb | Distal (>10kb) Multiome | 376 | |
| chr2:27,264,406–27,265,326 | 232.2 kb | Distal (>10kb) Multiome | 696 | |
| chr2:27,306,488–27,307,261 | 273.7 kb | Distal (>10kb) Multiome | 115 | |
| chr2:27,322,773–27,323,423 | 290.1 kb | Distal (>10kb) Multiome | 906 |
Genomic view of the TMEM214 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.