This gene consists of two exons and encodes a multi-pass membrane protein. An alternatively spliced transcript variant encoding the same protein has been found, but its biological validity is not determined. [provided by RefSeq, May 2010]
Transcription factors with Perturb-seq knockdown data for TMEM187. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM187 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM187, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:153,687,144–153,688,247 | 285.0 kb | Distal (>10kb) Multiome | 201 | |
| chrX:153,723,829–153,725,285 | 248.1 kb | Distal (>10kb) Multiome | 620 | |
| chrX:153,726,395–153,727,168 | 245.8 kb | Distal (>10kb) Multiome | 529 | |
| chrX:153,793,808–153,795,045 | 178.3 kb | Distal (>10kb) Multiome | 733 | |
| chrX:153,875,415–153,875,856 | 97.1 kb | Distal (>10kb) Multiome | 847 | |
| chrX:153,878,887–153,879,684 | 93.5 kb | Distal (>10kb) Multiome | 235 | |
| chrX:153,927,955–153,928,728 | 44.3 kb | Distal (>10kb) Multiome | 711 | |
| chrX:153,934,763–153,935,658 | 37.6 kb | Distal (>10kb) Multiome | 446 | |
| chrX:153,970,377–153,970,637 | 2.1 kb | Proximal (<10kb) | 203 | |
| chrX:153,970,913–153,973,065 | at TSS | At TSS | 857 | |
| chrX:154,097,040–154,098,161 | 125.1 kb | Distal (>10kb) Multiome | 537 | |
| chrX:154,136,648–154,137,146 | 164.1 kb | Distal (>10kb) Multiome | 391 |
Genomic view of the TMEM187 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.