Transcription factors with Perturb-seq knockdown data for TMEM18-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM18-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM18-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:513,683–514,911 | 163.0 kb | Distal (>10kb) Multiome | 139 | |
| chr2:676,032–677,904 | 142 bp | At TSS Multiome | 1125 | |
| chr2:739,661–741,352 | 63.5 kb | Distal (>10kb) Multiome | 302 | |
| chr2:949,713–951,620 | 273.5 kb | Distal (>10kb) Multiome | 318 |
Genomic view of the TMEM18-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.