Involved in endoplasmic reticulum tubular network organization; nuclear envelope organization; and nuclear pore complex assembly. Located in endoplasmic reticulum membrane and nuclear envelope. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM170A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM170A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM170A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:75,250,387–75,252,500 | 213.0 kb | Distal (>10kb) Multiome | 811 | |
| chr16:75,265,114–75,266,526 | 198.6 kb | Distal (>10kb) Multiome | 798 | |
| chr16:75,432,825–75,434,426 | 31.1 kb | Distal (>10kb) Multiome | 1143 | |
| chr16:75,455,694–75,456,000 | 8.7 kb | Proximal (<10kb) | 30 | |
| chr16:75,463,598–75,465,197 | 25 bp | At TSS Multiome | 999 | |
| chr16:75,471,834–75,472,040 | 7.1 kb | Proximal (<10kb) | 271 | |
| chr16:75,494,705–75,495,929 | 30.8 kb | Distal (>10kb) Multiome | 341 | |
| chr16:75,516,521–75,518,019 | 52.7 kb | Distal (>10kb) Multiome | 921 | |
| chr16:75,555,188–75,556,662 | 90.6 kb | Distal (>10kb) Multiome | 900 | |
| chr16:75,565,779–75,567,123 | 101.6 kb | Distal (>10kb) Multiome | 834 | |
| chr16:75,593,861–75,594,383 | 129.5 kb | Distal (>10kb) Multiome | 336 | |
| chr16:75,622,804–75,623,690 | 158.6 kb | Distal (>10kb) Multiome | 852 | |
| chr16:75,647,337–75,649,003 | 184.2 kb | Distal (>10kb) Multiome | 1002 | |
| chr16:77,133,565–77,134,646 | 1669.3 kb | Distal (>10kb) Multiome HiCAR | 131 | |
| chr16:77,211,464–77,213,653 | 1747.7 kb | Distal (>10kb) Multiome HiCAR | 644 |
Genomic view of the TMEM170A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.