Transcription factors with Perturb-seq knockdown data for TMEM147-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM147-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM147-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:35,247,580–35,249,688 | 297.3 kb | Distal (>10kb) Multiome | 1088 | |
| chr19:35,266,852–35,270,128 | 276.4 kb | Distal (>10kb) Multiome | 869 | |
| chr19:35,509,786–35,510,900 | 35.5 kb | Distal (>10kb) Multiome | 650 | |
| chr19:35,545,067–35,546,126 | 393 bp | At TSS Multiome | 879 | |
| chr19:35,549,256–35,549,470 | 3.7 kb | Proximal (<10kb) | 170 | |
| chr19:35,555,727–35,555,894 | 9.7 kb | Proximal (<10kb) | 180 | |
| chr19:35,557,343–35,558,684 | 12.0 kb | Distal (>10kb) Multiome | 452 | |
| chr19:35,612,546–35,613,176 | 66.7 kb | Distal (>10kb) Multiome | 778 | |
| chr19:35,628,465–35,629,474 | 82.9 kb | Distal (>10kb) Multiome | 889 | |
| chr19:35,643,064–35,645,730 | 97.5 kb | Distal (>10kb) Multiome | 1010 | |
| chr19:35,648,040–35,648,575 | 102.2 kb | Distal (>10kb) Multiome | 599 | |
| chr19:35,673,179–35,673,643 | 127.4 kb | Distal (>10kb) Multiome | 311 | |
| chr19:35,702,152–35,702,985 | 156.5 kb | Distal (>10kb) Multiome | 662 | |
| chr19:35,716,025–35,718,811 | 171.7 kb | Distal (>10kb) Multiome | 1018 | |
| chr19:35,740,083–35,741,430 | 194.8 kb | Distal (>10kb) Multiome | 829 | |
| chr19:35,744,481–35,746,086 | 199.2 kb | Distal (>10kb) Multiome | 679 | |
| chr19:35,748,170–35,749,017 | 202.4 kb | Distal (>10kb) Multiome | 749 | |
| chr19:35,757,432–35,758,657 | 212.1 kb | Distal (>10kb) Multiome | 851 | |
| chr19:35,767,601–35,768,256 | 221.9 kb | Distal (>10kb) Multiome | 276 | |
| chr19:35,775,066–35,776,063 | 229.5 kb | Distal (>10kb) Multiome | 474 | |
| chr19:35,784,357–35,785,306 | 238.7 kb | Distal (>10kb) Multiome | 183 |
Genomic view of the TMEM147-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.