Enables ubiquitin protein ligase activity. Involved in protein polyubiquitination; retrograde protein transport, ER to cytosol; and ubiquitin-dependent protein catabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM129. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM129 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM129, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:1,512,763–1,513,500 | 207.5 kb | Distal (>10kb) Multiome | 317 | |
| chr4:1,578,390–1,579,916 | 141.5 kb | Distal (>10kb) Multiome | 472 | |
| chr4:1,580,022–1,580,836 | 140.1 kb | Distal (>10kb) Multiome | 412 | |
| chr4:1,683,721–1,685,162 | 36.3 kb | Distal (>10kb) Multiome | 624 | |
| chr4:1,711,443–1,713,255 | 8.2 kb | Proximal (<10kb) Multiome | 1043 | |
| chr4:1,720,066–1,721,937 | 539 bp | At TSS Multiome | 817 | |
| chr4:1,726,178–1,726,532 | 5.4 kb | Proximal (<10kb) | 294 | |
| chr4:1,746,068–1,746,713 | 25.6 kb | Distal (>10kb) Multiome | 499 | |
| chr4:1,748,435–1,748,986 | 28.0 kb | Distal (>10kb) Multiome | 420 | |
| chr4:1,766,230–1,768,653 | 46.6 kb | Distal (>10kb) Multiome | 781 | |
| chr4:1,792,302–1,795,939 | 72.4 kb | Distal (>10kb) Multiome | 784 | |
| chr4:1,809,836–1,810,515 | 89.4 kb | Distal (>10kb) Multiome | 554 | |
| chr4:1,855,368–1,857,225 | 135.5 kb | Distal (>10kb) Multiome | 849 | |
| chr4:1,870,118–1,872,300 | 150.3 kb | Distal (>10kb) Multiome | 962 | |
| chr4:2,008,507–2,010,125 | 288.4 kb | Distal (>10kb) Multiome | 1040 |
Genomic view of the TMEM129 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.