TMEM120A

transmembrane protein 120A | NET29, TACAN, TMPIT

Enables coenzyme A binding activity. Involved in antiviral innate immune response; fat cell differentiation; and protein complex oligomerization. Located in endoplasmic reticulum and plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]

Member of: DE-1

Biological processes 27 terms

antiviral innate immune response (GO:0140374)antiviral innate immune response (GO:0140374)coenzyme A binding (GO:0120225)coenzyme A binding (GO:0120225)detection of mechanical stimulus involved in sensory perception of pain (GO:0050966)detection of mechanical stimulus involved in sensory perception of pain (GO:0050966)endoplasmic reticulum (GO:0005783)endoplasmic reticulum (GO:0005783)fat cell differentiation (GO:0045444)fat cell differentiation (GO:0045444)fat cell differentiation (GO:0045444)membrane (GO:0016020)membrane (GO:0016020)monoatomic ion channel activity (GO:0005216)monoatomic ion channel activity (GO:0005216)monoatomic ion channel activity (GO:0005216)monoatomic ion transmembrane transport (GO:0034220)monoatomic ion transmembrane transport (GO:0034220)nuclear inner membrane (GO:0005637)plasma membrane (GO:0005886)plasma membrane (GO:0005886)plasma membrane (GO:0005886)protein binding (GO:0005515)protein heterooligomerization (GO:0051291)protein heterooligomerization (GO:0051291)protein homooligomerization (GO:0051260)protein homooligomerization (GO:0051260)

Expression (TPM)

TFs regulating TMEM120A 0 TFs

Transcription factors with Perturb-seq knockdown data for TMEM120A. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM120A upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to TMEM120A

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM120A, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr7:75,738,406–75,739,915	255.4 kb	Distal (>10kb) Multiome	795
chr7:75,778,655–75,779,512	215.5 kb	Distal (>10kb) Multiome	54
chr7:75,780,667–75,781,151	213.8 kb	Distal (>10kb) Multiome	106
chr7:75,788,149–75,788,821	206.2 kb	Distal (>10kb) Multiome	95
chr7:75,878,577–75,879,573	115.6 kb	Distal (>10kb) Multiome	883
chr7:75,914,282–75,915,911	79.6 kb	Distal (>10kb) Multiome	1021
chr7:75,991,034–75,991,338	3.3 kb	Proximal (<10kb)	382
chr7:75,993,473–75,995,401	38 bp	At TSS Multiome	873
chr7:76,047,582–76,048,952	53.4 kb	Distal (>10kb) Multiome	920
chr7:76,073,173–76,073,663	78.9 kb	Distal (>10kb) Multiome	100
chr7:76,163,449–76,164,544	169.4 kb	Distal (>10kb) Multiome	132
chr7:76,166,338–76,167,166	172.1 kb	Distal (>10kb) Multiome	644
chr7:76,177,965–76,178,641	183.7 kb	Distal (>10kb) Multiome	670
chr7:76,201,356–76,202,307	207.2 kb	Distal (>10kb) Multiome	937
chr7:76,234,695–76,235,681	240.7 kb	Distal (>10kb) Multiome	329
chr7:76,259,707–76,261,052	265.8 kb	Distal (>10kb) Multiome	332
chr7:76,267,044–76,267,853	272.7 kb	Distal (>10kb) Multiome	211
chr7:76,282,299–76,283,220	288.1 kb	Distal (>10kb) Multiome	237
chr7:76,291,428–76,292,275	297.2 kb	Distal (>10kb) Multiome	767

Genome Browser

Genomic view of the TMEM120A locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.