Involved in positive regulation of canonical NF-kappaB signal transduction. Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMEM101. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMEM101 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMEM101, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:43,720,542–43,721,150 | 294.1 kb | Distal (>10kb) Multiome | 572 | |
| chr17:43,755,308–43,755,795 | 259.5 kb | Distal (>10kb) Multiome | 248 | |
| chr17:43,760,231–43,760,686 | 254.5 kb | Distal (>10kb) Multiome | 539 | |
| chr17:43,778,079–43,779,460 | 236.1 kb | Distal (>10kb) Multiome | 937 | |
| chr17:43,832,658–43,833,385 | 181.8 kb | Distal (>10kb) Multiome | 455 | |
| chr17:43,900,207–43,900,990 | 114.3 kb | Distal (>10kb) Multiome | 308 | |
| chr17:43,906,025–43,906,856 | 108.3 kb | Distal (>10kb) Multiome | 353 | |
| chr17:43,907,081–43,907,899 | 107.2 kb | Distal (>10kb) Multiome | 362 | |
| chr17:43,937,932–43,938,382 | 76.8 kb | Distal (>10kb) Multiome | 757 | |
| chr17:43,952,298–43,953,752 | 61.9 kb | Distal (>10kb) Multiome | 295 | |
| chr17:43,983,489–43,984,364 | 30.9 kb | Distal (>10kb) Multiome | 743 | |
| chr17:44,004,236–44,007,875 | 10.3 kb | Distal (>10kb) Multiome | 807 | |
| chr17:44,014,255–44,015,168 | 55 bp | At TSS Multiome | 1020 | |
| chr17:44,066,017–44,066,857 | 51.6 kb | Distal (>10kb) Multiome | 722 | |
| chr17:44,070,107–44,071,340 | 55.8 kb | Distal (>10kb) Multiome | 1041 | |
| chr17:44,095,480–44,096,263 | 81.0 kb | Distal (>10kb) Multiome | 713 | |
| chr17:44,110,949–44,111,605 | 96.3 kb | Distal (>10kb) Multiome | 856 | |
| chr17:44,122,999–44,124,340 | 108.8 kb | Distal (>10kb) Multiome | 883 | |
| chr17:44,141,505–44,142,741 | 126.9 kb | Distal (>10kb) Multiome | 857 | |
| chr17:44,168,259–44,168,849 | 153.6 kb | Distal (>10kb) Multiome | 475 | |
| chr17:44,186,111–44,187,514 | 171.9 kb | Distal (>10kb) Multiome | 917 | |
| chr17:44,198,550–44,201,037 | 185.2 kb | Distal (>10kb) Multiome | 868 | |
| chr17:44,210,257–44,210,930 | 195.6 kb | Distal (>10kb) Multiome | 568 | |
| chr17:44,218,107–44,221,629 | 203.7 kb | Distal (>10kb) Multiome | 936 | |
| chr17:44,221,765–44,222,816 | 207.3 kb | Distal (>10kb) Multiome | 597 | |
| chr17:44,307,755–44,309,164 | 293.5 kb | Distal (>10kb) Multiome | 726 | |
| chr17:44,314,945–44,315,776 | 300.3 kb | Distal (>10kb) Multiome | 273 |
Genomic view of the TMEM101 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.