Predicted to enable frizzled binding activity and smoothened binding activity. Involved in several processes, including Golgi organization; negative regulation of GTPase activity; and protein localization to plasma membrane. Located in Golgi apparatus; endoplasmic reticulum; and endoplasmic reticulum-Golgi intermediate compartment. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMED2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMED2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMED2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:123,232,511–123,233,923 | 351.4 kb | Distal (>10kb) Multiome HiCAR | 1073 | |
| chr12:123,269,375–123,269,864 | 314.8 kb | Distal (>10kb) Multiome HiCAR | 217 | |
| chr12:123,363,804–123,365,980 | 219.4 kb | Distal (>10kb) Multiome | 1015 | |
| chr12:123,383,367–123,384,963 | 200.6 kb | Distal (>10kb) Multiome | 836 | |
| chr12:123,388,500–123,389,409 | 195.7 kb | Distal (>10kb) Multiome | 446 | |
| chr12:123,436,072–123,436,895 | 147.9 kb | Distal (>10kb) Multiome | 742 | |
| chr12:123,458,045–123,458,697 | 126.1 kb | Distal (>10kb) Multiome | 925 | |
| chr12:123,533,444–123,534,540 | 50.6 kb | Distal (>10kb) Multiome | 718 | |
| chr12:123,583,890–123,585,003 | 71 bp | At TSS Multiome | 928 | |
| chr12:123,601,617–123,602,401 | 17.5 kb | Distal (>10kb) Multiome | 1076 | |
| chr12:123,633,273–123,633,970 | 49.2 kb | Distal (>10kb) Multiome | 886 | |
| chr12:123,670,899–123,671,414 | 86.5 kb | Distal (>10kb) Multiome | 469 | |
| chr12:123,711,684–123,712,955 | 127.7 kb | Distal (>10kb) Multiome | 771 | |
| chr12:123,719,176–123,720,140 | 135.1 kb | Distal (>10kb) Multiome | 303 | |
| chr12:123,761,832–123,763,058 | 177.5 kb | Distal (>10kb) Multiome | 416 |
Genomic view of the TMED2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.