This gene belongs to the TMED (transmembrane emp24 domain-containing) protein family, which is involved in the vesicular trafficking of proteins. The protein encoded by this gene was identified by its interaction with interleukin 1 receptor-like 1 (IL1RL1) and may play a role in innate immunity. This protein lacks any similarity to other interleukin 1 ligands. Alternative splicing results in multiple transcript variants of this gene. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for TMED1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMED1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMED1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:10,543,499–10,544,302 | 292.4 kb | Distal (>10kb) Multiome | 617 | |
| chr19:10,565,054–10,566,439 | 270.2 kb | Distal (>10kb) Multiome | 923 | |
| chr19:10,568,225–10,569,839 | 267.2 kb | Distal (>10kb) Multiome | 871 | |
| chr19:10,602,117–10,602,945 | 233.8 kb | Distal (>10kb) Multiome | 518 | |
| chr19:10,625,339–10,625,984 | 210.7 kb | Distal (>10kb) Multiome | 451 | |
| chr19:10,653,364–10,655,129 | 182.1 kb | Distal (>10kb) Multiome | 1086 | |
| chr19:10,695,264–10,696,403 | 140.3 kb | Distal (>10kb) Multiome | 831 | |
| chr19:10,701,273–10,702,291 | 134.8 kb | Distal (>10kb) Multiome | 889 | |
| chr19:10,717,121–10,718,717 | 118.4 kb | Distal (>10kb) Multiome | 849 | |
| chr19:10,835,171–10,836,835 | 298 bp | At TSS Multiome | 1096 | |
| chr19:10,870,403–10,872,620 | 35.0 kb | Distal (>10kb) Multiome | 714 | |
| chr19:10,928,331–10,929,395 | 92.5 kb | Distal (>10kb) Multiome | 860 | |
| chr19:10,960,232–10,961,863 | 124.7 kb | Distal (>10kb) Multiome | 1016 | |
| chr19:11,089,041–11,091,015 | 253.1 kb | Distal (>10kb) Multiome | 964 |
Genomic view of the TMED1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.