Predicted to be located in membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMCO4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMCO4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMCO4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:19,596,392–19,597,600 | 202.9 kb | Distal (>10kb) Multiome | 888 | |
| chr1:19,643,702–19,645,210 | 155.7 kb | Distal (>10kb) Multiome | 427 | |
| chr1:19,653,578–19,654,269 | 146.0 kb | Distal (>10kb) Multiome | 321 | |
| chr1:19,659,723–19,660,209 | 140.0 kb | Distal (>10kb) Multiome | 316 | |
| chr1:19,704,357–19,704,828 | 95.3 kb | Distal (>10kb) Multiome | 244 | |
| chr1:19,799,634–19,800,180 | at TSS | At TSS | 487 | |
| chr1:19,882,144–19,883,038 | 82.5 kb | Distal (>10kb) Multiome | 815 |
Genomic view of the TMCO4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.