Transcription factors with Perturb-seq knockdown data for TMCO1-AS1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMCO1-AS1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMCO1-AS1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:165,597,953–165,599,004 | 170.6 kb | Distal (>10kb) Multiome | 625 | |
| chr1:165,630,162–165,632,376 | 137.9 kb | Distal (>10kb) Multiome | 964 | |
| chr1:165,697,663–165,699,113 | 70.3 kb | Distal (>10kb) Multiome | 874 | |
| chr1:165,768,487–165,769,501 | 42 bp | At TSS Multiome | 853 | |
| chr1:165,776,661–165,776,897 | 7.7 kb | Proximal (<10kb) | 18 | |
| chr1:165,826,984–165,829,203 | 58.7 kb | Distal (>10kb) Multiome | 903 |
Genomic view of the TMCO1-AS1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.