Involved in amyloid precursor protein metabolic process. Located in endoplasmic reticulum. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMCC2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMCC2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMCC2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:205,121,687–205,122,681 | 105.7 kb | Distal (>10kb) Multiome | 1123 | |
| chr1:205,210,792–205,212,030 | 16.4 kb | Distal (>10kb) Multiome | 1103 | |
| chr1:205,227,416–205,228,381 | 96 bp | At TSS Multiome | 495 | |
| chr1:205,229,263–205,229,745 | 1.6 kb | Proximal (<10kb) Multiome | 331 | |
| chr1:205,300,603–205,302,127 | 73.6 kb | Distal (>10kb) Multiome | 660 | |
| chr1:205,313,308–205,314,407 | 86.1 kb | Distal (>10kb) Multiome | 327 | |
| chr1:205,321,242–205,322,079 | 93.8 kb | Distal (>10kb) Multiome | 705 | |
| chr1:205,343,395–205,344,420 | 116.0 kb | Distal (>10kb) Multiome | 395 | |
| chr1:205,430,507–205,431,109 | 202.9 kb | Distal (>10kb) Multiome | 387 | |
| chr1:205,440,982–205,441,976 | 213.3 kb | Distal (>10kb) Multiome | 341 | |
| chr1:205,444,530–205,445,576 | 217.2 kb | Distal (>10kb) Multiome | 351 | |
| chr1:205,447,468–205,447,874 | 219.6 kb | Distal (>10kb) Multiome | 135 | |
| chr1:205,448,352–205,449,283 | 220.8 kb | Distal (>10kb) Multiome | 269 | |
| chr1:205,449,573–205,450,965 | 222.3 kb | Distal (>10kb) Multiome | 512 | |
| chr1:205,456,289–205,457,681 | 229.4 kb | Distal (>10kb) Multiome | 383 | |
| chr1:205,485,282–205,485,813 | 257.6 kb | Distal (>10kb) Multiome | 590 | |
| chr1:205,504,221–205,505,625 | 276.7 kb | Distal (>10kb) Multiome | 631 |
Genomic view of the TMCC2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.