Transcription factors with Perturb-seq knockdown data for TMCC1-DT. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMCC1-DT upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMCC1-DT, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr3:129,605,081–129,607,497 | 286.9 kb | Distal (>10kb) Multiome | 686 | |
| chr3:129,626,284–129,628,391 | 267.0 kb | Distal (>10kb) Multiome | 862 | |
| chr3:129,794,539–129,795,151 | 99.0 kb | Distal (>10kb) Multiome | 376 | |
| chr3:129,892,830–129,894,307 | 90 bp | At TSS Multiome | 732 | |
| chr3:129,942,122–129,942,744 | 48.6 kb | Distal (>10kb) Multiome | 216 | |
| chr3:130,002,691–130,003,348 | 109.3 kb | Distal (>10kb) Multiome | 99 | |
| chr3:130,093,831–130,094,918 | 200.5 kb | Distal (>10kb) Multiome | 148 | |
| chr3:130,110,749–130,113,016 | 218.0 kb | Distal (>10kb) Multiome | 377 |
Genomic view of the TMCC1-DT locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.