Enables death receptor binding activity. Involved in negative regulation of Fas signaling pathway; negative regulation of extrinsic apoptotic signaling pathway via death domain receptors; and negative regulation of protein localization to plasma membrane. Located in Golgi membrane; endosome membrane; and lysosomal membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TMBIM1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TMBIM1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TMBIM1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:218,033,728–218,035,208 | 257.7 kb | Distal (>10kb) Multiome | 270 | |
| chr2:218,068,640–218,069,336 | 223.5 kb | Distal (>10kb) Multiome | 187 | |
| chr2:218,216,755–218,218,281 | 75.4 kb | Distal (>10kb) Multiome | 875 | |
| chr2:218,269,385–218,270,929 | 22.2 kb | Distal (>10kb) Multiome | 913 | |
| chr2:218,287,208–218,287,494 | 5.0 kb | Proximal (<10kb) | 393 | |
| chr2:218,290,037–218,290,611 | 2.3 kb | Proximal (<10kb) Multiome | 264 | |
| chr2:218,291,910–218,292,722 | 39 bp | At TSS Multiome | 695 | |
| chr2:218,301,357–218,301,580 | 8.8 kb | Proximal (<10kb) | 499 | |
| chr2:218,322,154–218,324,454 | 30.6 kb | Distal (>10kb) Multiome | 914 | |
| chr2:218,367,421–218,368,194 | 75.3 kb | Distal (>10kb) Multiome HiCAR | 450 | |
| chr2:218,387,091–218,388,220 | 95.4 kb | Distal (>10kb) Multiome HiCAR | 514 | |
| chr2:218,395,568–218,397,399 | 103.7 kb | Distal (>10kb) Multiome HiCAR | 1048 | |
| chr2:218,397,484–218,401,433 | 105.4 kb | Distal (>10kb) Multiome HiCAR | 1114 | |
| chr2:218,405,424–218,407,478 | 113.9 kb | Distal (>10kb) Multiome HiCAR | 1093 | |
| chr2:218,567,787–218,569,400 | 276.0 kb | Distal (>10kb) Multiome | 1083 |
Genomic view of the TMBIM1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.