The protein encoded by this gene contains a structural module related to that of the seven transmembrane domain G protein-coupled receptor superfamily. This protein has sequence and structural similarities to the beta-amyloid binding protein (BBP), but, unlike BBP, it does not regulate a response to beta-amyloid peptide. This protein may have regulatory roles in cell death or proliferation signal cascades. Several alternatively spliced transcript variants of this gene are described but the full length nature of some variants has not been determined. Multiple polyadenylation sites have been found in this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TM2D3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TM2D3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TM2D3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:100,601,704–100,603,366 | 1050.0 kb | Distal (>10kb) Multiome HiCAR | 808 | |
| chr15:101,294,732–101,295,714 | 357.1 kb | Distal (>10kb) Multiome HiCAR | 987 | |
| chr15:101,489,250–101,490,332 | 162.7 kb | Distal (>10kb) Multiome | 422 | |
| chr15:101,615,676–101,616,370 | 36.3 kb | Distal (>10kb) Multiome | 506 | |
| chr15:101,651,697–101,653,159 | 2 bp | At TSS Multiome | 1015 | |
| chr15:101,723,842–101,725,054 | 72.0 kb | Distal (>10kb) Multiome | 957 |
Genomic view of the TM2D3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.