This gene encodes a member of the Groucho/ transducin-like Enhancer of split family of transcriptional co-repressors. The encoded protein is a component of the mammalian subcortical maternal complex, which is required for preimplantation development. In mouse, knock out of this gene results in cleavage-stage embryonic arrest resulting from defective cytoplasmic F-actin meshwork formation and asymmetric cell division. In human, an allelic variant in this gene is associated with preimplantation embryonic lethality. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2016]
Transcription factors with Perturb-seq knockdown data for TLE6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TLE6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TLE6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:2,702,249–2,703,088 | 274.8 kb | Distal (>10kb) Multiome | 421 | |
| chr19:2,720,222–2,721,513 | 256.4 kb | Distal (>10kb) Multiome | 233 | |
| chr19:2,739,625–2,740,374 | 237.4 kb | Distal (>10kb) Multiome | 1063 | |
| chr19:2,782,866–2,783,778 | 194.1 kb | Distal (>10kb) Multiome | 998 | |
| chr19:2,784,850–2,785,981 | 192.1 kb | Distal (>10kb) Multiome | 682 | |
| chr19:2,819,641–2,820,625 | 157.7 kb | Distal (>10kb) Multiome | 826 | |
| chr19:2,840,664–2,842,136 | 136.2 kb | Distal (>10kb) Multiome | 903 | |
| chr19:2,900,564–2,901,033 | 76.7 kb | Distal (>10kb) Multiome | 686 | |
| chr19:2,944,631–2,945,468 | 32.5 kb | Distal (>10kb) Multiome | 891 | |
| chr19:2,950,070–2,951,291 | 26.8 kb | Distal (>10kb) Multiome | 962 | |
| chr19:2,976,688–2,977,848 | 143 bp | At TSS Multiome | 715 | |
| chr19:2,983,511–2,984,586 | 6.6 kb | Proximal (<10kb) Multiome | 523 | |
| chr19:2,987,265–2,987,622 | 9.7 kb | Proximal (<10kb) | 101 | |
| chr19:3,024,668–3,025,742 | 47.6 kb | Distal (>10kb) Multiome | 159 | |
| chr19:3,035,442–3,037,057 | 58.9 kb | Distal (>10kb) Multiome | 947 | |
| chr19:3,041,823–3,042,438 | 64.7 kb | Distal (>10kb) Multiome | 173 | |
| chr19:3,045,731–3,048,029 | 68.5 kb | Distal (>10kb) Multiome | 612 | |
| chr19:3,062,260–3,062,861 | 85.0 kb | Distal (>10kb) Multiome | 369 | |
| chr19:3,093,786–3,095,227 | 116.7 kb | Distal (>10kb) Multiome | 515 | |
| chr19:3,095,637–3,096,163 | 118.5 kb | Distal (>10kb) Multiome | 256 | |
| chr19:3,185,437–3,186,577 | 208.2 kb | Distal (>10kb) Multiome HiCAR | 751 | |
| chr19:3,275,036–3,277,129 | 298.7 kb | Distal (>10kb) Multiome | 737 |
Genomic view of the TLE6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.