Involved in several processes, including membrane assembly; phospholipid homeostasis; and regulation of membrane lipid distribution. Located in plasma membrane. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TLCD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TLCD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TLCD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:1,455,335–1,456,916 | 254.0 kb | Distal (>10kb) Multiome | 879 | |
| chr17:1,484,963–1,486,119 | 225.0 kb | Distal (>10kb) Multiome | 562 | |
| chr17:1,487,906–1,488,733 | 222.2 kb | Distal (>10kb) Multiome | 597 | |
| chr17:1,490,717–1,492,156 | 218.9 kb | Distal (>10kb) Multiome | 675 | |
| chr17:1,515,722–1,517,330 | 193.6 kb | Distal (>10kb) Multiome | 796 | |
| chr17:1,562,314–1,563,047 | 147.5 kb | Distal (>10kb) Multiome | 685 | |
| chr17:1,589,843–1,590,457 | 120.3 kb | Distal (>10kb) Multiome | 538 | |
| chr17:1,627,811–1,629,617 | 81.6 kb | Distal (>10kb) Multiome | 753 | |
| chr17:1,642,697–1,644,482 | 67.1 kb | Distal (>10kb) Multiome | 467 | |
| chr17:1,648,163–1,650,244 | 61.2 kb | Distal (>10kb) Multiome | 932 | |
| chr17:1,684,343–1,685,342 | 25.5 kb | Distal (>10kb) Multiome | 728 | |
| chr17:1,710,017–1,710,765 | 54 bp | At TSS Multiome | 500 | |
| chr17:1,713,886–1,717,908 | 7.1 kb | Proximal (<10kb) Multiome | 1042 | |
| chr17:1,724,373–1,725,206 | 14.4 kb | Distal (>10kb) Multiome | 720 | |
| chr17:1,829,368–1,830,287 | 119.6 kb | Distal (>10kb) Multiome HiCAR | 660 | |
| chr17:1,908,573–1,908,999 | 198.3 kb | Distal (>10kb) Multiome | 239 | |
| chr17:1,931,964–1,932,566 | 221.9 kb | Distal (>10kb) Multiome | 198 | |
| chr17:1,960,870–1,961,658 | 251.0 kb | Distal (>10kb) Multiome | 192 | |
| chr17:1,997,556–1,998,757 | 287.7 kb | Distal (>10kb) Multiome | 543 | |
| chr17:2,041,423–2,042,366 | 331.5 kb | Distal (>10kb) Multiome HiCAR | 834 | |
| chr17:2,048,764–2,051,218 | 338.7 kb | Distal (>10kb) Multiome HiCAR | 658 |
Genomic view of the TLCD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.