The protein encoded by this gene is part of the replisome complex, a group of proteins that support DNA replication. It binds TIM, which is involved in circadian rhythm regulation, and aids in protecting cells against DNA damage and stress. Two pseudogenes and two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]
Transcription factors with Perturb-seq knockdown data for TIPIN. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIPIN upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIPIN, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:66,252,061–66,253,967 | 104.2 kb | Distal (>10kb) Multiome | 412 | |
| chr15:66,293,215–66,294,349 | 63.0 kb | Distal (>10kb) Multiome | 772 | |
| chr15:66,356,371–66,357,196 | 60 bp | At TSS Multiome | 889 | |
| chr15:66,386,387–66,387,653 | 30.1 kb | Distal (>10kb) Multiome | 899 | |
| chr15:66,472,216–66,473,164 | 115.9 kb | Distal (>10kb) Multiome HiCAR | 208 | |
| chr15:66,497,104–66,498,247 | 141.1 kb | Distal (>10kb) Multiome HiCAR | 1044 | |
| chr15:66,504,543–66,505,655 | 148.4 kb | Distal (>10kb) Multiome | 940 | |
| chr15:66,567,056–66,567,492 | 210.6 kb | Distal (>10kb) Multiome | 294 | |
| chr15:66,592,463–66,593,143 | 236.1 kb | Distal (>10kb) Multiome | 154 | |
| chr15:66,621,672–66,622,446 | 265.5 kb | Distal (>10kb) Multiome | 271 | |
| chr15:66,630,856–66,631,340 | 274.4 kb | Distal (>10kb) Multiome | 284 | |
| chr15:66,670,796–66,671,740 | 314.5 kb | Distal (>10kb) Multiome | 241 | |
| chr15:66,673,331–66,673,903 | 317.0 kb | Distal (>10kb) Multiome | 192 | |
| chr15:66,679,362–66,680,264 | 323.2 kb | Distal (>10kb) Multiome | 541 |
Genomic view of the TIPIN locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.