This gene encodes one of the proteins of the shelterin, or telosome, complex which protects telomeres by allowing the cell to distinguish between telomeres and regions of DNA damage. The protein encoded by this gene is a critical part of shelterin; it interacts with the three DNA-binding proteins of the shelterin complex, and it is important for assembly of the complex. Mutations in this gene cause dyskeratosis congenita (DKC), an inherited bone marrow failure syndrome. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for TINF2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TINF2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TINF2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:23,953,479–23,954,293 | 288.5 kb | Distal (>10kb) Multiome | 897 | |
| chr14:23,988,469–23,989,172 | 253.5 kb | Distal (>10kb) Multiome | 439 | |
| chr14:24,036,218–24,036,993 | 205.8 kb | Distal (>10kb) Multiome | 627 | |
| chr14:24,051,239–24,052,875 | 190.4 kb | Distal (>10kb) Multiome | 821 | |
| chr14:24,080,914–24,082,038 | 160.9 kb | Distal (>10kb) Multiome | 706 | |
| chr14:24,093,491–24,095,115 | 148.1 kb | Distal (>10kb) Multiome | 990 | |
| chr14:24,113,681–24,115,917 | 127.4 kb | Distal (>10kb) Multiome | 1166 | |
| chr14:24,135,549–24,136,884 | 106.3 kb | Distal (>10kb) Multiome | 778 | |
| chr14:24,140,526–24,142,331 | 100.6 kb | Distal (>10kb) Multiome | 1034 | |
| chr14:24,146,204–24,148,108 | 95.5 kb | Distal (>10kb) Multiome | 918 | |
| chr14:24,160,877–24,161,762 | 81.1 kb | Distal (>10kb) Multiome | 970 | |
| chr14:24,171,489–24,172,698 | 70.5 kb | Distal (>10kb) Multiome | 365 | |
| chr14:24,188,229–24,189,111 | 53.5 kb | Distal (>10kb) Multiome | 1074 | |
| chr14:24,195,072–24,196,365 | 46.8 kb | Distal (>10kb) Multiome | 1059 | |
| chr14:24,212,871–24,213,884 | 28.9 kb | Distal (>10kb) Multiome | 1036 | |
| chr14:24,215,523–24,216,241 | 26.3 kb | Distal (>10kb) Multiome | 955 | |
| chr14:24,231,706–24,233,147 | 9.8 kb | Proximal (<10kb) Multiome | 1027 | |
| chr14:24,241,845–24,243,572 | 248 bp | At TSS Multiome | 1077 | |
| chr14:24,270,770–24,271,924 | 29.1 kb | Distal (>10kb) Multiome | 1089 | |
| chr14:24,299,120–24,300,273 | 57.4 kb | Distal (>10kb) Multiome HiCAR | 892 | |
| chr14:24,315,948–24,316,753 | 74.0 kb | Distal (>10kb) Multiome | 736 | |
| chr14:24,332,251–24,333,127 | 90.2 kb | Distal (>10kb) Multiome | 740 | |
| chr14:24,365,652–24,366,243 | 123.4 kb | Distal (>10kb) Multiome | 668 | |
| chr14:24,366,594–24,369,358 | 124.9 kb | Distal (>10kb) Multiome | 921 | |
| chr14:24,388,547–24,389,510 | 146.6 kb | Distal (>10kb) Multiome | 161 | |
| chr14:24,398,424–24,399,423 | 156.6 kb | Distal (>10kb) Multiome | 354 | |
| chr14:24,429,597–24,431,070 | 187.7 kb | Distal (>10kb) Multiome | 903 | |
| chr14:24,431,554–24,432,205 | 189.6 kb | Distal (>10kb) Multiome | 604 | |
| chr14:24,441,935–24,443,373 | 200.3 kb | Distal (>10kb) Multiome | 1072 | |
| chr14:24,481,599–24,482,121 | 239.5 kb | Distal (>10kb) Multiome | 593 |
Genomic view of the TINF2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.