Enables protein transporter activity. Involved in protein insertion into mitochondrial inner membrane. Located in mitochondrial inner membrane and mitochondrial intermembrane space. Part of TIM22 mitochondrial import inner membrane insertion complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TIMM29. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIMM29 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIMM29, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:10,653,364–10,655,129 | 274.7 kb | Distal (>10kb) Multiome | 1086 | |
| chr19:10,695,264–10,696,403 | 232.9 kb | Distal (>10kb) Multiome | 831 | |
| chr19:10,701,273–10,702,291 | 227.3 kb | Distal (>10kb) Multiome | 889 | |
| chr19:10,717,121–10,718,717 | 211.0 kb | Distal (>10kb) Multiome | 849 | |
| chr19:10,835,171–10,836,835 | 92.9 kb | Distal (>10kb) Multiome | 1096 | |
| chr19:10,870,403–10,872,620 | 57.6 kb | Distal (>10kb) Multiome | 714 | |
| chr19:10,928,331–10,929,395 | 104 bp | At TSS Multiome | 860 | |
| chr19:10,936,699–10,936,966 | 7.9 kb | Proximal (<10kb) | 281 | |
| chr19:10,960,232–10,961,863 | 32.1 kb | Distal (>10kb) Multiome | 1016 | |
| chr19:11,089,041–11,091,015 | 160.5 kb | Distal (>10kb) Multiome | 964 | |
| chr19:11,137,551–11,138,233 | 209.1 kb | Distal (>10kb) Multiome | 584 | |
| chr19:11,155,520–11,156,298 | 227.1 kb | Distal (>10kb) Multiome | 754 | |
| chr19:11,196,759–11,198,184 | 268.9 kb | Distal (>10kb) Multiome | 728 |
Genomic view of the TIMM29 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.