Involved in mitochondrial cytochrome c oxidase assembly; mitochondrial respiratory chain complex I assembly; and protein import into mitochondrial matrix. Located in mitochondrion. Part of TIM23 mitochondrial import inner membrane translocase complex. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for TIMM21. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIMM21 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIMM21, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr18:72,866,437–72,870,294 | 1280.5 kb | Distal (>10kb) Multiome HiCAR | 424 | |
| chr18:73,891,570–73,892,440 | 256.4 kb | Distal (>10kb) Multiome | 215 | |
| chr18:74,147,321–74,148,959 | 181 bp | At TSS Multiome | 990 | |
| chr18:74,281,103–74,282,795 | 134.2 kb | Distal (>10kb) Multiome | 450 | |
| chr18:74,290,874–74,292,549 | 143.6 kb | Distal (>10kb) Multiome | 848 |
Genomic view of the TIMM21 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.