The protein encoded by this gene belongs to the tigger subfamily of the pogo superfamily of DNA-mediated transposons in humans. These proteins are related to DNA transposons found in fungi and nematodes, and more distantly to the Tc1 and mariner transposases. They are also very similar to the major mammalian centromere protein B. The exact function of this gene is not known. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TIGD4. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TIGD4 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TIGD4, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:152,515,941–152,516,444 | 263.5 kb | Distal (>10kb) Multiome | 126 | |
| chr4:152,535,271–152,537,069 | 243.5 kb | Distal (>10kb) Multiome | 955 | |
| chr4:152,540,175–152,541,082 | 239.2 kb | Distal (>10kb) Multiome | 203 | |
| chr4:152,619,935–152,621,307 | 159.3 kb | Distal (>10kb) Multiome | 92 | |
| chr4:152,679,625–152,680,356 | 99.7 kb | Distal (>10kb) Multiome | 414 | |
| chr4:152,735,720–152,736,367 | 43.7 kb | Distal (>10kb) Multiome | 141 | |
| chr4:152,772,273–152,773,216 | 6.5 kb | Proximal (<10kb) | 61 | |
| chr4:152,779,006–152,780,778 | 135 bp | At TSS Multiome | 903 | |
| chr4:152,808,636–152,809,308 | 29.2 kb | Distal (>10kb) Multiome | 113 | |
| chr4:152,935,635–152,938,175 | 156.5 kb | Distal (>10kb) Multiome | 620 | |
| chr4:152,956,599–152,958,298 | 178.1 kb | Distal (>10kb) Multiome | 369 |
Genomic view of the TIGD4 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.